COUP-TF1 also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the NR2F1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. This protein is a member of nuclear hormone receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

  family of steroid hormone receptor

Steroid hormone receptor

Steroid hormone receptors are found on the plasma membrane, in the cytosol and also in the nucleus of target cells. They are generally intracellular receptors and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days...

s.

Function

Coup (chicken ovalbumin

Ovalbumin

Ovalbumin is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor...

 upstream promoter) transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

 binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.

Interactions

COUP-TFI has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with:

• BCL11A
  BCL11A
  B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.-Interactions:BCL11A has been shown to interact with COUP-TFI.- External links :...
  
  ,
• BCL11B
  BCL11B
  B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.- Function :This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not...
  
  ,
• COPS2
  COPS2
  COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.-Interactions:COPS2 has been shown to interact with IRF8, NIF3L1, Thyroid hormone receptor alpha and DAX1.-Further reading:...
  
  , and
• ESR1
  Estrogen receptor alpha
  Estrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...
  
  .

Further reading