BCL11B
Encyclopedia
B-cell lymphoma/leukemia 11B is a protein
that in humans is encoded by the BCL11B gene
.
protein and is closely related to BCL11A
, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel
) to form and work properly.
with COUP-TFI
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the BCL11B gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene encodes a C2H2-type zinc fingerZinc finger
Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
protein and is closely related to BCL11A
BCL11A
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.-Interactions:BCL11A has been shown to interact with COUP-TFI.- External links :...
, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel
Tooth enamel
Tooth enamel, along with dentin, cementum, and dental pulp is one of the four major tissues that make up the tooth in vertebrates. It is the hardest and most highly mineralized substance in the human body. Tooth enamel is also found in the dermal denticles of sharks...
) to form and work properly.
Interactions
BCL11B has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with COUP-TFI
COUP-TFI
COUP-TF1 also known as NR2F1 is a protein that in humans is encoded by the NR2F1 gene...
.