CED9 (gene)
Encyclopedia
Discovered in the C. elegans
genome. Ced9 is the gene that codes for a protein that inhibits/represses apoptosis
. The human version of the gene is called Bcl-2
.
The protein prevents the release of cytochrome c
in the membrane of mitochondria
http://www.wormbase.org/db/gene/gene?name=WBGene00000423;class=Gene
Caenorhabditis elegans
Caenorhabditis elegans is a free-living, transparent nematode , about 1 mm in length, which lives in temperate soil environments. Research into the molecular and developmental biology of C. elegans was begun in 1974 by Sydney Brenner and it has since been used extensively as a model...
genome. Ced9 is the gene that codes for a protein that inhibits/represses apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
. The human version of the gene is called Bcl-2
Bcl-2
Bcl-2 is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in...
.
The protein prevents the release of cytochrome c
Cytochrome c
The Cytochrome complex, or cyt c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins. Cytochrome c is a highly soluble protein, unlike other cytochromes, with a solubility of about 100 g/L and is an...
in the membrane of mitochondria
http://www.wormbase.org/db/gene/gene?name=WBGene00000423;class=Gene