C-8813
Encyclopedia
C-8813 is a potent μ-opioid
agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans isomer was found to be around 591x more potent than morphine
in animal studies. The same study assigned a potency of 504x morphine to BDPC.
C-8813 is claimed to be similarly potent at the δ-opioid receptor
, which antagonizes the mu depression of breathing, presumably making the drug safer.
C-8813 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation
, euphoria
, constipation
, itching and respiratory depression which could be harmful or fatal.
Mu Opioid receptor
The μ-opioid receptors are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ opioid peptide receptors. The prototypical μ receptor agonist is the opium alkaloid morphine; μ refers to morphine...
agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans isomer was found to be around 591x more potent than morphine
Morphine
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. It was first isolated in 1804 by Friedrich Sertürner, first distributed by same in 1817, and first commercially sold by Merck in 1827, which at the time was a single small chemists' shop. It was more...
in animal studies. The same study assigned a potency of 504x morphine to BDPC.
C-8813 is claimed to be similarly potent at the δ-opioid receptor
Delta Opioid receptor
The δ-opioid receptors, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an opioid receptor that has enkephalins as its endogenous ligands.-Function:...
, which antagonizes the mu depression of breathing, presumably making the drug safer.
C-8813 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation
Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure...
, euphoria
Euphoria (emotion)
Euphoria is medically recognized as a mental and emotional condition in which a person experiences intense feelings of well-being, elation, happiness, ecstasy, excitement and joy...
, constipation
Constipation
Constipation refers to bowel movements that are infrequent or hard to pass. Constipation is a common cause of painful defecation...
, itching and respiratory depression which could be harmful or fatal.