BufferGel
Encyclopedia
BufferGel is the brand name of a spermicide
and microbicide
gel which is being tested for its potential development into a preventative medicine to stop the transmission of HIV
.
were measured by vaginal colposcopy
and rectal lavage researchers determined that it fit the safety profile of a drug which could be tested on humans.
A phase I clinical trial done on women in India, Thailand gave supporting evidence that users tolerate the drug well. A similar trial in the United States also showed drug tolerance.
Spermicide
Spermicide is a contraceptive substance that eradicates sperm, inserted vaginally prior to intercourse to prevent pregnancy. As a contraceptive, spermicide may be used alone. However, the pregnancy rate experienced by couples using only spermicide is higher than that of couples using other methods...
and microbicide
Microbicide
Microbicides for sexually transmitted diseases, are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause human infection, for example the human immunodeficiency virus....
gel which is being tested for its potential development into a preventative medicine to stop the transmission of HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
.
Testing
In macaques, after BufferGel's effect on microflora and pHPH
In chemistry, pH is a measure of the acidity or basicity of an aqueous solution. Pure water is said to be neutral, with a pH close to 7.0 at . Solutions with a pH less than 7 are said to be acidic and solutions with a pH greater than 7 are basic or alkaline...
were measured by vaginal colposcopy
Colposcopy
Colposcopy is a medical diagnostic procedure to examine an illuminated, magnified view of the cervix and the tissues of the vagina and vulva. Many premalignant lesions and malignant lesions in these areas have discernible characteristics which can be detected through the examination...
and rectal lavage researchers determined that it fit the safety profile of a drug which could be tested on humans.
A phase I clinical trial done on women in India, Thailand gave supporting evidence that users tolerate the drug well. A similar trial in the United States also showed drug tolerance.