Bis(2-ethylhexyl) adipate
Encyclopedia
Bis adipate or DEHA is a plasticizer
Plasticizer
Plasticizers or dispersants are additives that increase the plasticity or fluidity of the material to which they are added; these include plastics, cement, concrete, wallboard, and clay. Although the same compounds are often used for both plastics and concretes the desired effects and results are...

. DEHA is an ester
Ester
Esters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH group is replaced by an -O-alkyl group, and most commonly from carboxylic acids and...

 of 2-ethylhexanol
2-Ethylhexanol
2-Ethylhexanol is a fatty alcohol, an organic compound is a branched, eight-carbon chiral alcohol. It is a colorless liquid that is nearly insoluble in water but soluble in most organic solvents...

 and adipic acid
Adipic acid
Adipic acid is the organic compound with the formula 42. From the industrial perspective, it is the most important dicarboxylic acid: About 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon...

. Its chemical formula is 22424.

DEHA is sometimes called "dioctyl adipate
Dioctyl adipate
Dioctyl adipate or DOA is a plasticizer. DOA is a diester of adipic acid and two equivalents of n-octanol. Its chemical formula is 22424.DEHA is sometimes incorrectly called dioctyl adipate....

", incorrectly. Other names include diisooctyl adipate and di(2-ethylhexyl) adipate.

Use

DEHA is used as a functional hydraulic fluid
Hydraulic fluid
Hydraulic fluids, also called hydraulic liquids, are the medium by which power is transferred in hydraulic machinery. Common hydraulic fluids are based on mineral oil or water...

, and a component of aircraft lubricant
Lubricant
A lubricant is a substance introduced to reduce friction between moving surfaces. It may also have the function of transporting foreign particles and of distributing heat...

s. It is sometimes also used as an ingredient in PVC
PVC
Polyvinyl chloride is a plastic.PVC may also refer to:*Param Vir Chakra, India's highest military honor*Peripheral venous catheter, a small, flexible tube placed into a peripheral vein in order to administer medication or fluids...

-based plastic wrap
Plastic wrap
Plastic wrap, cling film , cling wrap or food wrap, is a thin plastic film typically used for sealing food items in containers to keep them fresh over a longer period of time...

.

Toxicity

DEHA has been demonstrated to induce liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...

 adenoma
Adenoma
An adenoma is a benign tumor of glandular origin. Adenomas can grow from many organs including the colon, adrenal glands, pituitary gland, thyroid, prostate, etc. Although these growths are benign, over time they may progress to become malignant, at which point they are called adenocarcinomas...

s and carcinoma
Carcinoma
Carcinoma is the medical term for the most common type of cancer occurring in humans. Put simply, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that generally arises from cells originating in the endodermal or ectodermal germ layer during...

s in mice but not in rats. According to the International Agency for Research on Cancer
International Agency for Research on Cancer
The International Agency for Research on Cancer is an intergovernmental agency forming part of the World Health Organisation of the United Nations....

 (IARC), it is "not classifiable as to its carcinogenicity to humans (Group 3)," suggesting inadequate evidence of human carcinogenicity. While once on a U.S. Environmental Protection Agency‎ list of toxic chemicals under the Emergency Planning and Community Right-to-Know Act
Emergency Planning and Community Right-to-Know Act
The Emergency Planning and Community Right-to-Know Act of 1986 is a United States federal law passed by the 99th United States Congress located at Title 42, Chapter 116 of the U.S. Code, concerned with emergency response preparedness....

, it has been removed because it "cannot be reasonably anticipated to cause [...] irreversible chronic health effects."
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