Betazole
Encyclopedia
Betazole is a histamine H2 receptor agonist
. Also known as Ametazole. Betazole hydrochloride is known as gastramine and histalog.
It has been used as a gastric stimulant to test for maximal production of gastric secretion activity The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome
where there is excess acid production, in this case driven by over production of gastrin
. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease
It is also used in diagnosis of gastritis
in association with a test for secretin
activity
Betazole is used as a stimulant in preference to histamine because of its specificity for the H2 receptor and its advantage of not generating the undesirable side effects that histamine would induce. It therefore does not require concomitant use of antihistaminic compounds to block the actions of histamine at other histamine receptor types.
Its action in stimulating histamine release can be of use when testing the effectiveness of H2 receptor blocking drugs such as Nizatidine
.
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
. Also known as Ametazole. Betazole hydrochloride is known as gastramine and histalog.
It has been used as a gastric stimulant to test for maximal production of gastric secretion activity The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome
Zollinger-Ellison syndrome
Zollinger–Ellison syndrome is a triad of gastric acid hypersecretion, severe peptic ulceration, and non-beta cell islet tumor of pancreas . In this syndrome increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often the cause is a tumor of...
where there is excess acid production, in this case driven by over production of gastrin
Gastrin
In humans, gastrin is a peptide hormone that stimulates secretion of gastric acid by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the antrum of the stomach, duodenum, and the pancreas...
. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease
It is also used in diagnosis of gastritis
Gastritis
Gastritis is an inflammation of the lining of the stomach, and has many possible causes. The main acute causes are excessive alcohol consumption or prolonged use of nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen. Sometimes gastritis develops after major surgery, traumatic...
in association with a test for secretin
Secretin
Secretin is a hormone that controls the secretions into the duodenum, and also separately, water homeostasis throughout the body. It is produced in the S cells of the duodenum in the crypts of Lieberkühn...
activity
Betazole is used as a stimulant in preference to histamine because of its specificity for the H2 receptor and its advantage of not generating the undesirable side effects that histamine would induce. It therefore does not require concomitant use of antihistaminic compounds to block the actions of histamine at other histamine receptor types.
Its action in stimulating histamine release can be of use when testing the effectiveness of H2 receptor blocking drugs such as Nizatidine
Nizatidine
Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease...
.