Autophagy database
Encyclopedia
The Autophagy database is a database of proteins involved in autophagy
, a catabolic process involving the degradation of a cell's own components through the lysosomal
machinery. Its molecular mechanisms have not been fully elucidated, despite dramatic advances in the field as evidenced by hundreds of autophagy-related genes and proteins reported. The Autophagy database intends to collect all relevant information, organize it, and make it publicly available so that its users can easily get up-to-date knowledge.
Specifically, the database aims to make a comprehensive list of autophagy-related genes and proteins, identifies orthologs and other homologs, adds many kinds of information including sequences, functions, 3D structures, and makes them accessible in a searchable format. It also provides recently published references on autophagy with user ratings, a list of informative reviews, and results of an original analysis. The database was made publicly available in March 2010 and was updated to include 7,444 genes/proteins in 82 eukaryotes.
Autophagy
In cell biology, autophagy, or autophagocytosis, is a catabolic process involving the degradation of a cell's own components through the lysosomal machinery. It is a tightly regulated process that plays a normal part in cell growth, development, and homeostasis, helping to maintain a balance...
, a catabolic process involving the degradation of a cell's own components through the lysosomal
Lysosome
thumb|350px|Schematic of typical animal cell, showing subcellular components. [[Organelle]]s: [[nucleoli]] [[cell nucleus|nucleus]] [[ribosomes]] [[vesicle |vesicle]] rough [[endoplasmic reticulum]]...
machinery. Its molecular mechanisms have not been fully elucidated, despite dramatic advances in the field as evidenced by hundreds of autophagy-related genes and proteins reported. The Autophagy database intends to collect all relevant information, organize it, and make it publicly available so that its users can easily get up-to-date knowledge.
Specifically, the database aims to make a comprehensive list of autophagy-related genes and proteins, identifies orthologs and other homologs, adds many kinds of information including sequences, functions, 3D structures, and makes them accessible in a searchable format. It also provides recently published references on autophagy with user ratings, a list of informative reviews, and results of an original analysis. The database was made publicly available in March 2010 and was updated to include 7,444 genes/proteins in 82 eukaryotes.
External links
- http://tp-apg.genes.nig.ac.jp/autophagy
- Another database specializing in human autophagy (http://autophagy.lu/) is also publicly available.