Anticoagulant-induced skin necrosis
Encyclopedia
Anticoagulant-induced skin necrosis can be caused by both warfarin
Warfarin
Warfarin is an anticoagulant. It is most likely to be the drug popularly referred to as a "blood thinner," yet this is a misnomer, since it does not affect the thickness or viscosity of blood...

 and heparin
Heparin
Heparin , also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule...

. Though by different mechanism, obese, postmenopausal woman have a predisposition. Skin lesions tend to occur in areas with abundant subcutaneous fat such as the breast, abdomen, and buttocks. Warfarin necrosis occurs three to five days after therapy is begun, and a high initial dose increases risk. Heparin induced necrosis both at sites of local injection and in a widespread pattern when infused intravenously.
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