Amonafide
Encyclopedia
Amonafide (INN
, trade name Quinamed) is a drug that is being studied in the treatment of cancer
. It belongs to the families of drugs called topoisomerase inhibitor
s and DNA intercalators.
It is being developed as an anti-cancer therapy by Antisoma.
, it is in Phase III clinical trial
s.
eg In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).
International Nonproprietary Name
An International Nonproprietary Name is the official nonproprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization...
, trade name Quinamed) is a drug that is being studied in the treatment of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
. It belongs to the families of drugs called topoisomerase inhibitor
Topoisomerase inhibitor
Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymes , which are enzymes that control the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle.In recent years,...
s and DNA intercalators.
It is being developed as an anti-cancer therapy by Antisoma.
, it is in Phase III clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s.
eg In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).
External links
- Amonafide entry in the public domain NCI Dictionary of Cancer Terms
- Clinical trials of amonafide at ClinicalTrials.gov