Aminotransferase, class V
Encyclopedia
Aminotransferase class-V is an evolutionary conserved protein domain
. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. This family is called class-V.
; KYNU
; MOCOS
; NFS1
; PSAT1
; SCLY; TLH6;
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. This family is called class-V.
Subfamilies
- Phosphoserine aminotransferase
- Cysteine desulfuraseCysteine desulfuraseIn enzymology, a cysteine desulfurase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are L-cysteine and [enzyme]-cysteine, whereas its two products are L-alanine and [enzyme]-S-sulfanylcysteine....
- Cysteine desulphurase related, unknown function
- Cysteine desulphurases, SufS
- Cysteine desulphurase related
- 2-aminoethylphosphonate—pyruvate transaminase
Human proteins containing this domain
AGXTAGXT
Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.-External links:* -Further reading:...
; KYNU
Kynureninase
Kynureninase or L-Kynurenine hydrolase is a PLP dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid . It can also act on 3hKyn and some other -alanines...
; MOCOS
MOCOS
Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase and aldehyde oxidase , which is required for their enzymatic activities....
; NFS1
NFS1
Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the NFS1 gene.-Further reading:...
; PSAT1
PSAT1
Phosphoserine aminotransferase also known as phosphohydroxythreonine aminotransferase is an enzyme that in humans is encoded by the PSAT1 gene....
; SCLY; TLH6;