Alpha-v beta-3 - AbsoluteAstronomy.com

α_Vβ₃ is a type of integrin

Integrin

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They also play a role in cell signaling and thereby regulate cellular shape, motility, and the cell cycle....

that is a receptor for vitronectin

Vitronectin

Vitronectin also known as VTN is a protein that in humans is encoded by the VTN gene.The protein encoded by this gene is a member of the pexin family...

. It consists of two components, integrin alpha V

ITGAV

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.-Further reading:-External links:* Info with links in the...

and integrin beta 3

CD61

Integrin beta-3 or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.-Structure and function:...

(CD

Cluster of differentiation

The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells...

61), and is expressed by platelet

Platelet

Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...

s. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells.

Inhibitors like etaracizumab

Etaracizumab

Etaracizumab is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer, ovarian cancer and various other types of cancer. It is manufactured by MedImmune.-References:...

may be used as antiangiogenics.

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