Allotopic expression
Encyclopedia
Allotopic expression refers to expression from the nuclear
genome
of genes
that normally are expressed only from the mitochondrial genome. Biomedically engineered
AE has been suggested as a possible future tool in gene therapy
of certain mitochondria-related diseases (de Grey 2000), however this view is controversial (Oca-Cossio et al. 2003).
Atomic nucleus
The nucleus is the very dense region consisting of protons and neutrons at the center of an atom. It was discovered in 1911, as a result of Ernest Rutherford's interpretation of the famous 1909 Rutherford experiment performed by Hans Geiger and Ernest Marsden, under the direction of Rutherford. The...
genome
Genome
In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....
of genes
Gênes
Gênes is the name of a département of the First French Empire in present Italy, named after the city of Genoa. It was formed in 1805, when Napoleon Bonaparte occupied the Republic of Genoa. Its capital was Genoa, and it was divided in the arrondissements of Genoa, Bobbio, Novi Ligure, Tortona and...
that normally are expressed only from the mitochondrial genome. Biomedically engineered
Biomedical engineering
Biomedical Engineering is the application of engineering principles and design concepts to medicine and biology. This field seeks to close the gap between engineering and medicine: It combines the design and problem solving skills of engineering with medical and biological sciences to improve...
AE has been suggested as a possible future tool in gene therapy
Gene therapy
Gene therapy is the insertion, alteration, or removal of genes within an individual's cells and biological tissues to treat disease. It is a technique for correcting defective genes that are responsible for disease development...
of certain mitochondria-related diseases (de Grey 2000), however this view is controversial (Oca-Cossio et al. 2003).