Align-m
Encyclopedia
Align-m is a multiple sequence alignment
program written by Ivo Van Walle.
Align-m has the ability to accomplish the following tasks:
Multiple sequence alignment
A multiple sequence alignment is a sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutionary relationship by which they share a lineage and are descended from a common ancestor...
program written by Ivo Van Walle.
Align-m has the ability to accomplish the following tasks:
- Multiple sequence alignment
- Include extra information to guide the sequence alignment
- Multiple structural alignmentStructural alignmentStructural alignment attempts to establish homology between two or more polymer structures based on their shape and three-dimensional conformation. This process is usually applied to protein tertiary structures but can also be used for large RNA molecules...
- Homology modelingHomology modelingHomology modeling, also known as comparative modeling of protein refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein...
by (iteratively) combining sequence and structure alignment data - 'Filtering' of BLASTBLASTIn bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences...
or other pairwise alignments - Combining many alignments into one consensus sequenceConsensus sequenceIn molecular biology and bioinformatics, consensus sequence refers to the most common nucleotide or amino acid at a particular position after multiple sequences are aligned. A consensus sequence is a way of representing the results of a multiple sequence alignment, where related sequences are...
- Multiple genome alignment (can cope with rearrangements)