Alexander Schmidt (physiologist)
Encyclopedia
Alexander Schmidt was a Livonian physiologist. He was born on the Island of Mohn, which today is called Muhu
Muhu
Muhu , is an island in the Baltic Sea. With an area of 198 km² it is the third largest island belonging to Estonia, after Saaremaa and Hiiumaa....

, Estonia
Estonia
Estonia , officially the Republic of Estonia , is a state in the Baltic region of Northern Europe. It is bordered to the north by the Gulf of Finland, to the west by the Baltic Sea, to the south by Latvia , and to the east by Lake Peipsi and the Russian Federation . Across the Baltic Sea lies...

. In 1858, he received his medical doctorate from the University of Dorpat, and later was an assistant to Felix Hoppe-Seyler (1825-1895) in Berlin
Berlin
Berlin is the capital city of Germany and is one of the 16 states of Germany. With a population of 3.45 million people, Berlin is Germany's largest city. It is the second most populous city proper and the seventh most populous urban area in the European Union...

, and Carl Ludwig
Carl Ludwig
----Carl Friedrich Wilhelm Ludwig was a German physician and physiologist.In 1842 Ludwig became a professor of physiology and in 1846 of comparative anatomy...

 (1816-1895) in Leipzig
Leipzig
Leipzig Leipzig has always been a trade city, situated during the time of the Holy Roman Empire at the intersection of the Via Regia and Via Imperii, two important trade routes. At one time, Leipzig was one of the major European centres of learning and culture in fields such as music and publishing...

. In 1869 he succeeded Friedrich Bidder (1810-1894) as professor of physiology at Dorpat, where he remained for the rest of his life.

Schmidt is remembered for his research involving the process of blood coagulation by demonstrating that the transformation of fibrinogen
Fibrinogen
Fibrinogen is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for...

 into fibrin
Fibrin
Fibrin is a fibrous, non-globular protein involved in the clotting of blood. It is a fibrillar protein that is polymerised to form a "mesh" that forms a hemostatic plug or clot over a wound site....

 was the result of an enzymatic
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

 process. He named the hypothetical enzyme "thrombin
Thrombin
Thrombin is a "trypsin-like" serine protease protein that in humans is encoded by the F2 gene. Prothrombin is proteolytically cleaved to form thrombin in the first step of the coagulation cascade, which ultimately results in the stemming of blood loss...

", and he called its precursor "prothrombin". Schmidt is credited for providing the foundation for the creation of anti-coagulation systems and the development of blood transfusion
Blood transfusion
Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood...

.

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