Aldosterone-to-renin ratio
Encyclopedia
Aldosterone-to-renin ratio (ARR) is the mass concentration
of aldosterone
divided by the plasma renin activity in blood plasma. The aldosterone/renin ratio is recommended as screening tool for primary hyperaldosteronism.
of the aldosterone-to-renin ratio.
The cutoff for distinguishing normal individuals from those with primary hyperaldosteronism is significantly affected by the conditions of testing, such as posture and time of day. On average, an ARR cutoff of 23.6 ng/dL per ng/(mL·h), expressed in alternative units as 650 pmol/liter per µg/(liter·h), has been estimated to have a sensitivity
of 97% and specificity
of 94%. A value in an individual that is higher than the cutoff indicates primary hyperaldosteronism.
Mass concentration
In astronomy or astrophysics mass concentration or mascon is a region of a planet or moon's crust that contains a large positive gravitational anomaly. In general, the word "mascon" can be used as a noun to describe an excess distribution of mass on or beneath the surface of a planet , such as Hawaii...
of aldosterone
Aldosterone
Aldosterone is a hormone that increases the reabsorption of sodium ions and water and the release of potassium in the collecting ducts and distal convoluted tubule of the kidneys' functional unit, the nephron. This increases blood volume and, therefore, increases blood pressure. Drugs that...
divided by the plasma renin activity in blood plasma. The aldosterone/renin ratio is recommended as screening tool for primary hyperaldosteronism.
Interpretation
Aldosterone-to-renin ratio can be given in ng/dL per ng/(mL·h), that is, nanogram per decilitre of aldosterone per nanogram per (millilitre x hour) of renin. Also, it can be given in pmol/liter per µg/(liter·h), where aldosterone is given in molar concentration. The former can be converted to the latter by multiplying with 27.6. Also, the inverse value is occasionally given, that is, the renin-to-aldosterone ratio, whose value is the multiplicative inverseMultiplicative inverse
In mathematics, a multiplicative inverse or reciprocal for a number x, denoted by 1/x or x−1, is a number which when multiplied by x yields the multiplicative identity, 1. The multiplicative inverse of a fraction a/b is b/a. For the multiplicative inverse of a real number, divide 1 by the...
of the aldosterone-to-renin ratio.
The cutoff for distinguishing normal individuals from those with primary hyperaldosteronism is significantly affected by the conditions of testing, such as posture and time of day. On average, an ARR cutoff of 23.6 ng/dL per ng/(mL·h), expressed in alternative units as 650 pmol/liter per µg/(liter·h), has been estimated to have a sensitivity
Sensitivity and specificity
Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as classification function. Sensitivity measures the proportion of actual positives which are correctly identified as such Sensitivity and specificity are statistical...
of 97% and specificity
Sensitivity and specificity
Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as classification function. Sensitivity measures the proportion of actual positives which are correctly identified as such Sensitivity and specificity are statistical...
of 94%. A value in an individual that is higher than the cutoff indicates primary hyperaldosteronism.
| Aldosterone-to-renin ratio | Renin-to-aldosterone ratio | |||
|---|---|---|---|---|
| Value | Unit | Value | Unit | |
| 13.1, 23.6, 35.0 | ng/dl per ng/(ml·h) | 0.029, 0.042, 0.076 | ng/(ml·h) per ng/dl | |
| 360, 650, 960 | pmol/liter per µg/(liter·h) | 0.0010, 0.0015, 0.0028 | µg/(liter·h) per pmol/liter | |