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Actimel
Encyclopedia
Launched in Europe in 1994, Actimel (also known as DanActive in the United States
and Canada
) is a 'probiotic
' yoghurt
-type drink produced by the French company Danone. It is sold in 100ml bottles, typically as an 8, 6 or 4 pack, but more recently as a 12 or 16 pack. The main claimed benefit of Actimel is the strengthening of the body's natural defences through the use of patented bacterial culture called Lactobacillus casei
DN-114001, marketed as Lactobacillus casei Defensis or Immunitas(s) and more recently as L. casei Danone. Each bottle is claimed to contain 10 billion of these bacteria. In addition Actimel contains the traditional yoghurt cultures Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus salivarius subsp. thermophilus
.
After the introduction of Yakult
in Europe in 1993 several other companies including Danone responded releasing their own L. casei based products. Since 1994, L. casei based yogurts have become a common product in West European supermarkets.
Actimel earned over €1400 million (US$1.8 billion) in retail sales in 2006 and can be found in more than 20 European countries as well as in South America and the Middle East. Actimel was released as DanActive in the United States
on a limited regional basis in 2004 (flavours Strawberry, Vanilla, and Blueberry) then was given a nationwide launch in 2007 (adding the flavour Cranberry/Raspberry).
Claimed benefits range from reducing the incidence of diarrhea
and rhinitis reduction for young children , to improvement of the immune function in adults) and seniors
and reduction of duration of winter infections for elderly.
Some clinical studies suggest potential effects for children such as eradication of H. pylori when combined with antibiotics or restoration of activity of fecal enzymes in children after surgery.
A recent study published by the British Medical Journal suggests that the product could help to avoid antibiotic–associated diarrhea and limit Clostridium difficile
infections in elderly patients.
Research is ongoing to determine the effectiveness, or otherwise, of this product in reducing the occurrence of common illnesses in children attending daycare centers in the US. This clinical trial has been registered clinicaltrials.gov (as is now often required for peer-reviewed publication, in order to decrease the likelihood of null results being unreported), but results are not published as yet.
.
On January 23, 2008, a proposed class action was filed in California
, accusing Danone Co. Inc. of false advertising in their marketing of yogurt containing probiotic bacteria (Danactive & Activia), alleging that the claimed health benefits have never been proven. The company has denied this accusation.
Foodwatch
claims that Danone "makes a mountain out of a molehill" in suggesting that Actimel protects from cold and boosts health. Foodwatch believes that the company sells a commodity product as a niche product using branding.
The Advertising Standards Authority (ASA) is an independent regulator for advertisements, sales promotion and direct marketing in the UK. According to Spiegel Online one TV spot from Actimel was blocked by the ASA in 2006 and one in 2008. In the first case the ASA upheld a complaint that the advert misleadingly implied that children given Actimel would be prevented from catching bacterial infections. Meanwhile in the second case complaints about the use of the phrase "Actimel is scientifically proven and you can see that proof for yourself on our website" were upheld as only summaries of, or references to, these studies were present on the website and the full content was not available. A TV advert which stated that Actimel was "scientifically-proven to help support your kids' defences" was banned by the Advertising Standards Authority.
Alexa Meyer, from the Department of Nutritional Sciences, University of Vienna, Austria, comparing probiotic drinks and normal yoghurt, found no significant difference in the effect of Actimel and normal yogurt with living bacteria. The nutritional researcher recommends to get enough sleep, wash hands often and eat a daily bowl of yoghurt. She says this would activate more active germ-fighting white blood cells, enhancing the immune system, probably due to the presence of Lactobacillus bulgaricus, from any normal yogurt, which is half the price of Actimel.
The equivalence of yoghurts is supported by Berthold Koletzko from the University of Munich, Metabolic Diseases and Nutrition, Munich, Germany in case of diarrhoea advises parents to give their children yogurt with living bacteria. It does not necessarily need to be Actimel, but may also be other yogurts. A measurable health benefit linked to the presence of live Streptococcus thermophilus and Lactobacillus delbrueckii sp. Bulgaricus was reported by Koletzko and colleagues 2005 yoghurt. In this review Koletzko and colleagues say that it was clearly demonstrated that yoghurt containing viable bacteria improves lactose digestion and eliminates symptoms of lactose intolerance, and clearly fulfil the current concept of probiotics.
The net "all-cause" effects of yoghurts have also been questioned; its September 6, 2009 issue, Nature
featured an article by Didier Raoult who claimed that "probiotic-enriched" yogurt beverages may have contributed to the increase in obesity over the past 20 years.
Within the 27 countries of the European Union, a new health claims regulation was put in place by the European Commission as of July 1, 2007, under which companies who wish to make claims about the nutritional & functional benefits of a product must support the claims with scientific evidence. In Canada, a similar regulation is currently in the works at Health Canada, as it plans to update its assessment framework to make the system clearer and the claims more credible.
(described for concentrations of sugar above 15 g per 100 g). As a comparison, Coca-Cola and orange juices are also in the range of 10 g of sugar per 100 g, but with a serving size usually higher than 250 ml the total sugar quantity is much higher.
Through nutrient profiling guidelines, current health claim regulations in the European Union may forbid the use of health claim on food products that are nutritionally unbalanced, but dairy products and probiotic drinks are likely to be considered favourably because their health benefits outweigh the fact they are high in one of the designated 'unhealthy' ingredients.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
and Canada
Canada
Canada is a North American country consisting of ten provinces and three territories. Located in the northern part of the continent, it extends from the Atlantic Ocean in the east to the Pacific Ocean in the west, and northward into the Arctic Ocean...
) is a 'probiotic
Probiotic
Probiotics are live microorganisms thought to be beneficial to the host organism. According to the currently adopted definition by FAO/WHO, probiotics are: "Live microorganisms which when administered in adequate amounts confer a health benefit on the host"...
' yoghurt
Yoghurt
Yoghurt, yogurt or yogourt is a dairy product produced by bacterial fermentation of milk. The bacteria used to make yoghurt are known as "yoghurt cultures"...
-type drink produced by the French company Danone. It is sold in 100ml bottles, typically as an 8, 6 or 4 pack, but more recently as a 12 or 16 pack. The main claimed benefit of Actimel is the strengthening of the body's natural defences through the use of patented bacterial culture called Lactobacillus casei
Lactobacillus casei
Lactobacillus casei is a species of genus Lactobacillus found in the human intestine and mouth. As a lactic acid producer, it has been found to assist in the propagation of desirable bacteria. This particular species of Lactobacillus is documented to have a wide pH and temperature range, and...
DN-114001, marketed as Lactobacillus casei Defensis or Immunitas(s) and more recently as L. casei Danone. Each bottle is claimed to contain 10 billion of these bacteria. In addition Actimel contains the traditional yoghurt cultures Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus salivarius subsp. thermophilus
Streptococcus salivarius subsp. thermophilus
Streptococcus salivarius subsp. thermophilus is a Gram-positive bacteria and a homofermentative facultative anaerobe, of the viridans group. It tests negative for cytochrome, oxidase and catalase, and positive for alpha-hemolytic activity...
.
After the introduction of Yakult
Yakult
is a Japanese probiotic milk-like product made by fermenting a mixture of skimmed milk with a special strain of the bacterium Lactobacillus casei Shirota. It was created by Minoru Shirota who graduated from the Medical School of Kyoto University in 1930. In 1935, he started manufacturing and...
in Europe in 1993 several other companies including Danone responded releasing their own L. casei based products. Since 1994, L. casei based yogurts have become a common product in West European supermarkets.
Actimel earned over €1400 million (US$1.8 billion) in retail sales in 2006 and can be found in more than 20 European countries as well as in South America and the Middle East. Actimel was released as DanActive in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
on a limited regional basis in 2004 (flavours Strawberry, Vanilla, and Blueberry) then was given a nationwide launch in 2007 (adding the flavour Cranberry/Raspberry).
Ingredients
Standard Actimel (excludes variations such as Actimel Light) contains:- Milk (freshMilkMilk is a white liquid produced by the mammary glands of mammals. It is the primary source of nutrition for young mammals before they are able to digest other types of food. Early-lactation milk contains colostrum, which carries the mother's antibodies to the baby and can reduce the risk of many...
/powderedPowdered milkPowdered milk is a manufactured dairy product made by evaporating milk to dryness. One purpose of drying milk is to preserve it; milk powder has a far longer shelf life than liquid milk and does not need to be refrigerated, due to its low moisture content. Another purpose is to reduce its bulk for...
) - Sugar (sucroseSucroseSucrose is the organic compound commonly known as table sugar and sometimes called saccharose. A white, odorless, crystalline powder with a sweet taste, it is best known for its role in human nutrition. The molecule is a disaccharide composed of glucose and fructose with the molecular formula...
) - Live Lactobacillus caseiLactobacillus caseiLactobacillus casei is a species of genus Lactobacillus found in the human intestine and mouth. As a lactic acid producer, it has been found to assist in the propagation of desirable bacteria. This particular species of Lactobacillus is documented to have a wide pH and temperature range, and...
DN-114001 probiotic strain, 10 000 million per 100 mL bottle - Live yoghurt cultures
Scientific basis
The main claimed benefits are referenced to several scientific studies listed by the manufacturer on various of its websites, . The list of scientific papers differs on each country's website.Claimed benefits range from reducing the incidence of diarrhea
Diarrhea
Diarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...
and rhinitis reduction for young children , to improvement of the immune function in adults) and seniors
and reduction of duration of winter infections for elderly.
Some clinical studies suggest potential effects for children such as eradication of H. pylori when combined with antibiotics or restoration of activity of fecal enzymes in children after surgery.
A recent study published by the British Medical Journal suggests that the product could help to avoid antibiotic–associated diarrhea and limit Clostridium difficile
Clostridium difficile
Clostridium difficile , also known as "CDF/cdf", or "C...
infections in elderly patients.
Research is ongoing to determine the effectiveness, or otherwise, of this product in reducing the occurrence of common illnesses in children attending daycare centers in the US. This clinical trial has been registered clinicaltrials.gov (as is now often required for peer-reviewed publication, in order to decrease the likelihood of null results being unreported), but results are not published as yet.
Debates surrounding health claims on probiotic foods
See also Health claims on food labelsHealth claims on food labels
Health claims on food labels are claims by manufacturers of food products that their food will reduce the risk of developing a disease or condition...
.
On January 23, 2008, a proposed class action was filed in California
California
California is a state located on the West Coast of the United States. It is by far the most populous U.S. state, and the third-largest by land area...
, accusing Danone Co. Inc. of false advertising in their marketing of yogurt containing probiotic bacteria (Danactive & Activia), alleging that the claimed health benefits have never been proven. The company has denied this accusation.
Foodwatch
Foodwatch
Foodwatch is a German organization that focuses on protecting consumer rights and food quality. was founded in October 2002 in Berlin by former Greenpeace executive director Thilo Bode....
claims that Danone "makes a mountain out of a molehill" in suggesting that Actimel protects from cold and boosts health. Foodwatch believes that the company sells a commodity product as a niche product using branding.
The Advertising Standards Authority (ASA) is an independent regulator for advertisements, sales promotion and direct marketing in the UK. According to Spiegel Online one TV spot from Actimel was blocked by the ASA in 2006 and one in 2008. In the first case the ASA upheld a complaint that the advert misleadingly implied that children given Actimel would be prevented from catching bacterial infections. Meanwhile in the second case complaints about the use of the phrase "Actimel is scientifically proven and you can see that proof for yourself on our website" were upheld as only summaries of, or references to, these studies were present on the website and the full content was not available. A TV advert which stated that Actimel was "scientifically-proven to help support your kids' defences" was banned by the Advertising Standards Authority.
Alexa Meyer, from the Department of Nutritional Sciences, University of Vienna, Austria, comparing probiotic drinks and normal yoghurt, found no significant difference in the effect of Actimel and normal yogurt with living bacteria. The nutritional researcher recommends to get enough sleep, wash hands often and eat a daily bowl of yoghurt. She says this would activate more active germ-fighting white blood cells, enhancing the immune system, probably due to the presence of Lactobacillus bulgaricus, from any normal yogurt, which is half the price of Actimel.
The equivalence of yoghurts is supported by Berthold Koletzko from the University of Munich, Metabolic Diseases and Nutrition, Munich, Germany in case of diarrhoea advises parents to give their children yogurt with living bacteria. It does not necessarily need to be Actimel, but may also be other yogurts. A measurable health benefit linked to the presence of live Streptococcus thermophilus and Lactobacillus delbrueckii sp. Bulgaricus was reported by Koletzko and colleagues 2005 yoghurt. In this review Koletzko and colleagues say that it was clearly demonstrated that yoghurt containing viable bacteria improves lactose digestion and eliminates symptoms of lactose intolerance, and clearly fulfil the current concept of probiotics.
The net "all-cause" effects of yoghurts have also been questioned; its September 6, 2009 issue, Nature
Nature (journal)
Nature, first published on 4 November 1869, is ranked the world's most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports...
featured an article by Didier Raoult who claimed that "probiotic-enriched" yogurt beverages may have contributed to the increase in obesity over the past 20 years.
Within the 27 countries of the European Union, a new health claims regulation was put in place by the European Commission as of July 1, 2007, under which companies who wish to make claims about the nutritional & functional benefits of a product must support the claims with scientific evidence. In Canada, a similar regulation is currently in the works at Health Canada, as it plans to update its assessment framework to make the system clearer and the claims more credible.
Nutrition facts
Danone Actimel plain 0% actually contains 3.3 g of sugar, original plain contains 10.5 g of sugar, multifruit contains 12.0 g of sugar for every serving (100 g). None of those concentrations is higher than the level defined as “HIGH” by the UK Food Standards AgencyFood Standards Agency
The Food Standards Agency is a non-ministerial government department of the Government of the United Kingdom. It is responsible for protecting public health in relation to food throughout the United Kingdom and is led by a board appointed to act in the public interest...
(described for concentrations of sugar above 15 g per 100 g). As a comparison, Coca-Cola and orange juices are also in the range of 10 g of sugar per 100 g, but with a serving size usually higher than 250 ml the total sugar quantity is much higher.
Through nutrient profiling guidelines, current health claim regulations in the European Union may forbid the use of health claim on food products that are nutritionally unbalanced, but dairy products and probiotic drinks are likely to be considered favourably because their health benefits outweigh the fact they are high in one of the designated 'unhealthy' ingredients.
External links
- Actimel website
- Actimel website in the UK
- DanActive - Actimel in the US
- Danone - The manufacturers of Actimel
- Dannon - Dannon in the US
- bifidobacteriumanimalis.com - A deconstruction of the terms Bifidus Digestivum, Bifidus Regularis, L. Casei Immunitas and their variants, as well as the marketing strategy, and information about the potential health benefits of live yogurts.