2CBFly-NBOMe
Encyclopedia
2CBFly-NBOMe is a compound indirectly derived from the phenethylamine
hallucinogen
2C-B
, and related to benzodifurans like 2C-B-FLY
and N-benzylphenethylamines like NBOMe-2C-I. It was discovered in 2002, and further researched by Ralf Heim at the Free University of Berlin
, and subsequently investigated in more detail by a team at Purdue University
led by David Nichols. It acts as a potent partial agonist
for the 5HT2A serotonin
receptor
subtype, with a Ki
of 0.14nM at the rat 5HT2A receptor.
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
hallucinogen
Psychedelic
The term psychedelic is derived from the Greek words ψυχή and δηλοῦν , translating to "soul-manifesting". A psychedelic experience is characterized by the striking perception of aspects of one's mind previously unknown, or by the creative exuberance of the mind liberated from its ostensibly...
2C-B
2C-B
2C-B or 4-bromo-2,5-dimethoxyphenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred...
, and related to benzodifurans like 2C-B-FLY
2C-B-FLY
2C-B-FLY is a psychedelic phenethylamine of the 2C family. It was first synthesized by Aaron P. Monte.-Chemistry:2C-B-FLY is 8-bromo-2,3,6,7-benzo-dihydro-difuran-ethylamine. The full name of the chemical is 2-ethanamine...
and N-benzylphenethylamines like NBOMe-2C-I. It was discovered in 2002, and further researched by Ralf Heim at the Free University of Berlin
Free University of Berlin
Freie Universität Berlin is one of the leading and most prestigious research universities in Germany and continental Europe. It distinguishes itself through its modern and international character. It is the largest of the four universities in Berlin. Research at the university is focused on the...
, and subsequently investigated in more detail by a team at Purdue University
Purdue University
Purdue University, located in West Lafayette, Indiana, U.S., is the flagship university of the six-campus Purdue University system. Purdue was founded on May 6, 1869, as a land-grant university when the Indiana General Assembly, taking advantage of the Morrill Act, accepted a donation of land and...
led by David Nichols. It acts as a potent partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
for the 5HT2A serotonin
Serotonin
Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
subtype, with a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 0.14nM at the rat 5HT2A receptor.
See also
- 2CBCB-NBOMe2CBCB-NBOMe2CBCB-NBOMe is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2007 at Purdue University as part of the ongoing research program of the team led by David Nichols focusing on the mapping of the specific amino acid residues responsible for...
(NBOMe-TCB-2) - 2C-C-NBOMe2C-C-NBOMe2C-C-NBOMe is a derivative of the phenethylamine hallucinogen 2C-C, which acts as a potent partial agonist for the 5HT2A receptor, and has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission...
(NBOMe-2CC) - 25B-NBOMe25B-NBOMe25B-NBOMe is a derivative of the phenethylamine hallucinogen 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin. It acts as a potent partial agonist for the 5HT2A receptor...
(NBOMe-2CB) - 25I-NBMD25I-NBMD25I-NBMD is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2006 by a team at Purdue University led by David Nichols. It acts as a potent partial agonist for the 5HT2A receptor with a Ki of 0.049nM at the human 5HT2A receptor...
(NBMD-2CI) - 25I-NBOH25I-NBOH25I-NBOH is a derivative of the phenethylamine derived hallucinogen 2C-I, discovered in 2006 by a team at Purdue University. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.12nM at the human 5HT2A receptor, making it some 5x the potency of 2C-I itself...
(NBOH-2CI) - 25I-NBOMe25I-NBOMe25I-NBOMe is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2003 by Ralf Heim at the Free University of Berlin, and subsequently investigated in more detail by a team at Purdue University led by David Nichols.25I-NBOMe acts as a highly potent agonist for the human 5-HT2A...
(NBOMe-2CI) - 2C-TFM-NBOMe2C-TFM-NBOMe2C-TFM-NBOMe is a derivative of the phenethylamine hallucinogen 2C-TFM, discovered in 2004 by Ralf Heim at the Free University of Berlin...
(NBOMe-2C-TFM) - 25I-NBF25I-NBF25I-NBF is a derivative of the phenethylamine hallucinogen 2C-I, which acts as a highly potent partial agonist for the human 5-HT2A receptor...
(NBF-2CI)