2C-TFM-NBOMe
Encyclopedia
2C-TFM-NBOMe is a derivative of the phenethylamine
hallucinogen
2C-TFM
, discovered in 2004 by Ralf Heim at the Free University of Berlin
. It acts as a potent partial agonist
for the 5HT2A receptor
, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe
, while others show it to be of similar or higher potency, possibly because of differences in the assay used.
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
hallucinogen
Psychedelic
The term psychedelic is derived from the Greek words ψυχή and δηλοῦν , translating to "soul-manifesting". A psychedelic experience is characterized by the striking perception of aspects of one's mind previously unknown, or by the creative exuberance of the mind liberated from its ostensibly...
2C-TFM
2C-TFM
2C-TFM is a psychedelic phenethylamine of the 2C family. It was first synthesized in the laboratory of David E. Nichols. It has also been called 2C-CF3, a name derived from the para-trifluoromethyl group it contains.-Chemistry:...
, discovered in 2004 by Ralf Heim at the Free University of Berlin
Free University of Berlin
Freie Universität Berlin is one of the leading and most prestigious research universities in Germany and continental Europe. It distinguishes itself through its modern and international character. It is the largest of the four universities in Berlin. Research at the university is focused on the...
. It acts as a potent partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
for the 5HT2A receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe
25I-NBOMe
25I-NBOMe is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2003 by Ralf Heim at the Free University of Berlin, and subsequently investigated in more detail by a team at Purdue University led by David Nichols.25I-NBOMe acts as a highly potent agonist for the human 5-HT2A...
, while others show it to be of similar or higher potency, possibly because of differences in the assay used.
See also
- DOTFMDOTFM2,5-Dimethoxy-4-trifluoromethylamphetamine is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols. DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in...
- TFMFlyTFMFlyTFMFly is a compound related to phenethylamine hallucinogens such as 2C-B-FLY and 2C-TFM. It was first reported in 2005 by a team at Purdue University led by David Nichols. It acts as a potent agonist at the 5HT2A serotonin receptor subtype, and is a chiral compound with the more active enantiomer...
- 2CBCB-NBOMe2CBCB-NBOMe2CBCB-NBOMe is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2007 at Purdue University as part of the ongoing research program of the team led by David Nichols focusing on the mapping of the specific amino acid residues responsible for...
(NBOMe-TCB-2) - 2CBFly-NBOMe2CBFly-NBOMe2CBFly-NBOMe is a compound indirectly derived from the phenethylamine hallucinogen 2C-B, and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like NBOMe-2C-I...
(NBOMe-2CB-Fly) - 2C-C-NBOMe2C-C-NBOMe2C-C-NBOMe is a derivative of the phenethylamine hallucinogen 2C-C, which acts as a potent partial agonist for the 5HT2A receptor, and has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission...
(NBOMe-2CC) - 25B-NBOMe25B-NBOMe25B-NBOMe is a derivative of the phenethylamine hallucinogen 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin. It acts as a potent partial agonist for the 5HT2A receptor...
(NBOMe-2CB) - 25I-NBOMe25I-NBOMe25I-NBOMe is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2003 by Ralf Heim at the Free University of Berlin, and subsequently investigated in more detail by a team at Purdue University led by David Nichols.25I-NBOMe acts as a highly potent agonist for the human 5-HT2A...
(NBOMe-2CI) - 25I-NBMD25I-NBMD25I-NBMD is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2006 by a team at Purdue University led by David Nichols. It acts as a potent partial agonist for the 5HT2A receptor with a Ki of 0.049nM at the human 5HT2A receptor...
(NBMD-2CI) - 25I-NBOH25I-NBOH25I-NBOH is a derivative of the phenethylamine derived hallucinogen 2C-I, discovered in 2006 by a team at Purdue University. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.12nM at the human 5HT2A receptor, making it some 5x the potency of 2C-I itself...
(NBOH-2CI) - 25I-NBF25I-NBF25I-NBF is a derivative of the phenethylamine hallucinogen 2C-I, which acts as a highly potent partial agonist for the human 5-HT2A receptor...
(NBF-2CI)