2-Methyl-2-nitrosopropane
Encyclopedia
2-Methyl-2-nitrosopropane (MNP or t-nitrosobutane, chemical formula (CH3)3CNO) can be prepared by catalytic oxidation of (CH3)3CNH2 using hydrogen peroxide
Hydrogen peroxide
Hydrogen peroxide is the simplest peroxide and an oxidizer. Hydrogen peroxide is a clear liquid, slightly more viscous than water. In dilute solution, it appears colorless. With its oxidizing properties, hydrogen peroxide is often used as a bleach or cleaning agent...

 and sodium tungstate
Sodium tungstate
Sodium tungstate, Na2WO4, a tungstate of sodium, is useful as a source of tungsten. It is prepared from tungsten ores used to manufacture tungsten by reducing it....

. Depending on the temperature and solvent, it is either dimeric and colorless or monomeric and blue. It can be used as a spin trap
Spin trapping
Spin trapping in chemistry is an analytical technique employed in the detection and identification of short-lived free radicals. Spin trapping involves the addition of radical to a nitrone spin trap resulting in the formation of a spin adduct, a nitroxide-based persistent radical, that can be...

. This molecule traps unstable free radicals to form stable paramagnetic nitroxide radicals that can be detected and analyzed by electron spin resonance spectroscopy. It is particularly useful for trapping carbon-centered tyrosyl radicals.

MNP is also the aerial oxidation product of t-butylhydroxylamine (NtBHA), which in turn is a hydrolysis product of phenylbutylnitrone and similar spintraps. MNP has pharmacological action, both by scavenging free radicals and possibly by releasing the messenger substance nitric oxide
Nitric oxide
Nitric oxide, also known as nitrogen monoxide, is a diatomic molecule with chemical formula NO. It is a free radical and is an important intermediate in the chemical industry...

 in the presence of light and under oxidizing conditions. Production of NtHBA and its parent spintrap MNP may account for the sometime antistroke action of the drug NXY-059
NXY-059
Disufenton sodium is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone or "PBN". It was under development at the drug company AstraZeneca. A 2005 phase-3 clinical trial called "SAINT-1" reported some efficacy in the acute treatment of ischemia injury due to stroke...

.

MNP is also an efficient regulator of the radical polymerization
Polymerization
In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form three-dimensional networks or polymer chains...

 of methyl methacrylate
Methyl methacrylate
Methyl methacrylate is an organic compound with the formula CH2=CCOOCH3. This colourless liquid, the methyl ester of methacrylic acid is a monomer produced on a large scale for the production of poly .-Production:...

through the 'pseudoliving' chain mechanism.
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