Offseason

• October 8, 1959: Randy Jackson was released by the Cubs.
• October 30, 1959: Del Rice
  Del Rice
  Delbert Rice Jr. was an American professional baseball player, coach and manager. He played for 17 seasons as a catcher in Major League Baseball from to , most notably for the St. Louis Cardinals...
  
   was signed as a free agent by the Cubs.
• December 6, 1959: Lee Walls
  Lee Walls
  Raymond Lee Walls, Jr. , is a former professional baseball player who played outfield in the Major Leagues from 1953-1964. Walls would play for the Chicago Cubs, Pittsburgh Pirates, Cincinnati Reds, Philadelphia Phillies, and Los Angeles Dodgers. He also played one season in Japan in 1965 for the...
  
  , Lou Jackson, and Bill Henry
  Bill Henry
  William Rodman Henry is a retired American professional baseball player. A left-handed pitcher, he appeared in Major League Baseball between and for the Boston Red Sox, Chicago Cubs, Cincinnati Reds, San Francisco Giants, Pittsburgh Pirates, and Houston Astros...
  
   were traded by the Cubs to the Cincinnati Reds
  Cincinnati Reds
  The Cincinnati Reds are a Major League Baseball team based in Cincinnati, Ohio. They are members of the National League Central Division. The club was established in 1882 as a charter member of the American Association and joined the National League in 1890....
  
   for Frank Thomas.

Notable transactions

• April 8, 1960: Ron Perranoski
  Ron Perranoski
  Ronald Peter Perranoski is a former left-handed Major League Baseball relief pitcher, having played from through ....
  
  , Johnny Goryl
  Johnny Goryl
  John Albert Goryl is a special adviser/player development for the Cleveland Indians and a former infielder, manager and coach in American Major League Baseball....
  
  , Lee Handley (minors), and $25,000 were traded by the Cubs to the Los Angeles Dodgers
  Los Angeles Dodgers
  The Los Angeles Dodgers are a professional baseball team based in Los Angeles, California. The Dodgers are members of Major League Baseball's National League West Division. Established in 1883, the team originated in Brooklyn, New York, where it was known by a number of nicknames before becoming...
  
   for Don Zimmer
  Don Zimmer
  Donald William "Popeye" Zimmer is a former infielder, manager, and coach in Major League Baseball, currently serving as a senior advisor to the Tampa Bay Rays baseball organization...
  
  .
• May 13, 1960: Tony Taylor
  Tony Taylor
  Antonio Nemesio Taylor is a former second baseman in Major League Baseball. From 1958 through , Taylor played for the Chicago Cubs , Philadelphia Phillies and Detroit Tigers...
  
   and Cal Neeman
  Cal Neeman
  Calvin Amandus Neeman , is a retired professional baseball player who played catcher in the Major Leagues from -. He would play for the Pittsburgh Pirates, Washington Senators, Chicago Cubs, Philadelphia Phillies, and Cleveland Indians. He is an alumnus of Illinois Wesleyan University.-External...
  
   were traded by the Cubs to the Philadelphia Phillies
  Philadelphia Phillies
  The Philadelphia Phillies are a Major League Baseball team. They are the oldest continuous, one-name, one-city franchise in all of professional American sports, dating to 1883. The Phillies are a member of the Eastern Division of Major League Baseball's National League...
  
   for Don Cardwell
  Don Cardwell
  Donald Eugene Cardwell was an American right-handed pitcher in Major League Baseball who played for five National League teams from 1957 to 1970...
  
   and Ed Bouchee
  Ed Bouchee
  Edward Francis Bouchee is a former Major League Baseball first baseman who played from to . He finished second in the Rookie of the Year voting in , hitting .293 with 17 home runs and 76 RBI. Those would all prove to be career highs.After the 1957 season was over, Bouchee was arrested for...
  
  .
• June 4, 1960: Del Rice was released by the Cubs.
• July 15, 1960: Earl Averill
  Earl Averill, Jr.
  Earl Douglas Averill, Jr. , is a former professional baseball player who played catcher in the Major Leagues from 1956-1963. He played for the Chicago Cubs, Chicago White Sox, Los Angeles Angels, Philadelphia Phillies, and Cleveland Indians.-External links:...
  
   and $30,000 were traded by the Cubs to the Milwaukee Braves
  Atlanta Braves
  The Atlanta Braves are a professional baseball club based in Atlanta, Georgia. The Braves are a member of the Eastern Division of Major League Baseball's National League. The Braves have played in Turner Field since 1997....
  
   for Al Heist
  Al Heist
  Alfred Michael "Al" Heist was a Major League Baseball outfielder for the Chicago Cubs , and the Houston Colt .45's...
  
  .

Roster

Starters by position

Other batters

Starting pitchers

Other pitchers

Relief pitchers

Farm system