12-Hydroxyeicosatetraenoic acid
Encyclopedia
12-Hydroxyeicosatetraenoic acid (12-HETE) is an eicosanoid
. It is a metabolite of arachidonic acid
produced by the action of the enzyme arachidonate 12-lipoxygenase
. 12-HETE is a highly selective ligand used to label mu opioid receptor
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Eicosanoid
In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, ....
. It is a metabolite of arachidonic acid
Arachidonic acid
Arachidonic acid is a polyunsaturated omega-6 fatty acid 20:4.It is the counterpart to the saturated arachidic acid found in peanut oil, Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).It is the counterpart to the saturated arachidic acid found in peanut oil,...
produced by the action of the enzyme arachidonate 12-lipoxygenase
Arachidonate 12-lipoxygenase
In enzymology, an arachidonate 12-lipoxygenase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are arachidonate and O2, whereas its product is --12-hydroperoxyicosa-5,8,10,14-tetraenoate....
. 12-HETE is a highly selective ligand used to label mu opioid receptor
Mu Opioid receptor
The μ-opioid receptors are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ opioid peptide receptors. The prototypical μ receptor agonist is the opium alkaloid morphine; μ refers to morphine...
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