(1-Pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone
Encyclopedia
-(2,2,3,3-tetramethylcyclopropyl)methanone is a drug invented by Abbott Laboratories
, that acts as a selective full agonist of the peripheral cannabinoid receptor
CB2, but with much lower affinity for the psychoactive CB1 receptor. It has high affinity for the CB2 receptor with a Ki of 1.8nM but 83x lower affinity for the CB1 receptor with a Ki of 150nM. Chemically it is closely related to other 2,2,3,3-tetramethylcyclopropyl synthetic cannabinoids like A-796,260
and A-834,735
but with a different substitution on the 1-position of indole core, its 1-pentyl group replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).
Abbott Laboratories
Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....
, that acts as a selective full agonist of the peripheral cannabinoid receptor
Cannabinoid receptor
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...
CB2, but with much lower affinity for the psychoactive CB1 receptor. It has high affinity for the CB2 receptor with a Ki of 1.8nM but 83x lower affinity for the CB1 receptor with a Ki of 150nM. Chemically it is closely related to other 2,2,3,3-tetramethylcyclopropyl synthetic cannabinoids like A-796,260
A-796,260
A-796,260 is a drug developed by Abbott Laboratories which acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids with the 3-tetramethylcyclopropylmethanone group, imparts significant...
and A-834,735
A-834,735
A-834,735 is a drug developed by Abbott Laboratories which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2...
but with a different substitution on the 1-position of indole core, its 1-pentyl group replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).
See also
- AB-001AB-001AB-001 or 1-pentyl-3-indole is a designer drug which was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary in 2011...
- JWH-018JWH-018JWH-018 or AM-678 is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2...
- N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamideN-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide7-methoxy-1--N--1H-indole-3-carboxamide is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors...