ZEB2
Encyclopedia
Zinc finger E-box-binding homeobox 2 is a protein
that in humans is encoded by the ZEB2 gene
.
)/Zfh1 family of 2-handed zinc finger
/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMAD
s.
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Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the ZEB2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
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Function
The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (TCF8ZEB1
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription...
)/Zfh1 family of 2-handed zinc finger
Zinc finger
Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMAD
SMAD (protein)
SMADs are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream TGF-β gene transcription....
s.
Clinical significance
Mutations in the ZEB2 gene is associated with the Mowat-Wilson syndromeMowat-Wilson Syndrome
Mowat Wilson syndrome is a rare genetic disorder that was clinically delineated by Dr. D. R. Mowat and Dr. M. J. Wilson in 1998.-Presentation:...
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