Y box binding protein 1
Encyclopedia
Y box binding protein 1, officially known as YBX1, but commonly referred to as "YB-1" by researchers, is a human protein
. Current research is examining its involvement in cancer, and particularly in the metastasis
of cancerous cells or prevention thereof.
with RBBP6
, PCNA
, ANKRD2
, SFRS9
, CTCF
and P53
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
. Current research is examining its involvement in cancer, and particularly in the metastasis
Metastasis
Metastasis, or metastatic disease , is the spread of a disease from one organ or part to another non-adjacent organ or part. It was previously thought that only malignant tumor cells and infections have the capacity to metastasize; however, this is being reconsidered due to new research...
of cancerous cells or prevention thereof.
Interactions
Y box binding protein 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with RBBP6
RBBP6
Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.-Interactions:RBBP6 has been shown to interact with Y box binding protein 1.-Further reading:...
, PCNA
PCNA
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...
, ANKRD2
ANKRD2
Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene.-Interactions:ANKRD2 has been shown to interact with Y box binding protein 1, Telethonin, Promyelocytic leukemia protein and P53.-Further reading:...
, SFRS9
SFRS9
Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.-Interactions:SFRS9 has been shown to interact with Y box binding protein 1 and NOL3....
, CTCF
CTCF
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene...
and P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
.