XPO1
Encyclopedia
Exportin-1 is a protein
that in humans is encoded by the XPO1 gene
.
with NMD3
, CIITA
, RANBP3
, Nucleoporin 62
, Ran
, RANBP1
, APC
, SMARCB1
and CDKN1B
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the XPO1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
XPO1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NMD3
NMD3
60S ribosomal export protein NMD3 is a protein that in humans is encoded by the NMD3 gene.-Further reading:...
, CIITA
CIITA
CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection...
, RANBP3
RANBP3
Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.-Interactions:RANBP3 has been shown to interact with RCC1 and XPO1.-Further reading:...
, Nucleoporin 62
Nucleoporin 62
Nucleoporin p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues...
, Ran
Ran (biology)
Ran is a small 25Kda protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily....
, RANBP1
RANBP1
Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.-Interactions:RANBP1 has been shown to interact with XPO1, KPNB1 and Ran.-Further reading:...
, APC
APC (gene)
Adenomatous polyposis coli also known as deleted in polyposis 2.5 is a protein that in humans is encoded by the APC gene. Mutations in the APC gene may result in colorectal cancer....
, SMARCB1
SMARCB1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...
and CDKN1B
CDKN1B
Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4...
.