Witzelsucht
Encyclopedia
Witzelsucht, from the German witzeln, meaning to joke or wisecrack, and sucht meaning addiction or yearning, is a set of rare neurological symptoms characterized by the patient's uncontrollable tendency to make pun
Pun
The pun, also called paronomasia, is a form of word play which suggests two or more meanings, by exploiting multiple meanings of words, or of similar-sounding words, for an intended humorous or rhetorical effect. These ambiguities can arise from the intentional use and abuse of homophonic,...

s, tell inappropriate jokes and pointless or irrelevant stories at inconvenient moments. The patient nevertheless finds these utterances intensely amusing.

It is associated with small lesions of the orbitofrontal cortex
Orbitofrontal cortex
The orbitofrontal cortex is a prefrontal cortex region in the frontal lobes in the brain which is involved in the cognitive processing of decision-making...

.

It is distinguished from pathologic laughing by virtue of congruent affective experience and expression, and an admixture of irritability and mirth. It is most commonly seen in patients with frontal lobe
Frontal lobe
The frontal lobe is an area in the brain of humans and other mammals, located at the front of each cerebral hemisphere and positioned anterior to the parietal lobe and superior and anterior to the temporal lobes...

disease or injury, particularly right frontal lobe tumors or trauma. Elderly people are very prone to this disorder because of the decreased mass of their gray tissue. For instance, the stereotype of the wise-cracking grandfather may have originated from this.
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