Winfried Denk
Encyclopedia
Winfried Denk is a German physicist
Physicist
A physicist is a scientist who studies or practices physics. Physicists study a wide range of physical phenomena in many branches of physics spanning all length scales: from sub-atomic particles of which all ordinary matter is made to the behavior of the material Universe as a whole...

 and neurobiologist, director of the Max-Plack-Institute for Medical Research in Heidelberg. He is noted for being the first to implement two-photon microscopy while a postdoctoral fellow in Watt W. Webb
Watt W. Webb
Watt W. Webb is known for his co-invention of Multiphoton microscopy in 1990.- Biography :Professor Watt W...

's lab in 1990. Denk later (1994) recognized that two-photon microscopy has unique properties for imaging live cells deep in highly scattering tissues. His second major invention is a machine that automatically acquires three-dimensional images at a resolution of a few nanometers. This technique, known as Serial Block-Face Scanning Electron Microscopy
Serial Block-Face Scanning Electron Microscopy
Serial block-face scanning electron microscopy is a method to generate high resolution three-dimensional images from biological samples such as brain tissue. It consists of an ultramicrotome mounted inside the vacuum chamber of a scanning electron microscope...

 (SBFSEM), has been commercialized by the company Gatan. For his achievements, Winfried Denk was awarded the Gottfried Wilhelm Leibniz Prize
Gottfried Wilhelm Leibniz Prize
The Gottfried Wilhelm Leibniz Prize is a research prize awarded by the Deutsche Forschungsgemeinschaft every year since 1985 to scientists working in Germany. This highest German research prize consists of a research grant of 2.5 million euro, to be used within seven years...

in 2003.

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