Watson syndrome
Encyclopedia
Watson syndrome is an autosomal recessive condition characterized by Lisch nodules, axillary/inguinal freckling, and neurofibroma
s.
Watson syndrome may be allelic
to NF1
, the same gene associated with Neurofibromatosis type 1.
Neurofibroma
A neurofibroma is a benign nerve sheath tumor in the peripheral nervous system. Usually found in individuals with neurofibromatosis type I , an autosomal dominant genetically-inherited disease, they can result in a range of symptoms from physical disfiguration and pain to cognitive disability...
s.
Watson syndrome may be allelic
Allele
An allele is one of two or more forms of a gene or a genetic locus . "Allel" is an abbreviation of allelomorph. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation...
to NF1
Neurofibromin 1
Neurofibromin 1 also known as neurofibromatosis-related protein NF-1 is a protein that in humans is encoded by the NF1 gene. Mutations in the NF1 gene are associated with neurofibromatosis type I .- Function :NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the...
, the same gene associated with Neurofibromatosis type 1.