WWC1
Encyclopedia
Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein
that in humans is encoded by the WWC1 gene
.
A single nucleotide polymorphism
(rs17070145) in the gene has been association with human memory performance in one 2006 study. No significant support for association with memory was found in a large study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.
Studies have also begun to investigate the role of KIBRA in Alzheimer's disease
.
For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.
KIBRA has been shown to interact
with Protein kinase Mζ.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the WWC1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
A single nucleotide polymorphism
Polymorphism (biology)
Polymorphism in biology occurs when two or more clearly different phenotypes exist in the same population of a species — in other words, the occurrence of more than one form or morph...
(rs17070145) in the gene has been association with human memory performance in one 2006 study. No significant support for association with memory was found in a large study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.
Studies have also begun to investigate the role of KIBRA in Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
.
Interactions
KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity.For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.
KIBRA has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Protein kinase Mζ.