WDR75
Encyclopedia
WDR75 is a human protein encoded by the WDR75 gene containing a WD40 superfamily domain. The WD40 domain is found throughout many eukaryotic cell
types and is known to be involved in cellular regulator functions such as pre-mRNA
processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the scientific community
.
is 830 residues long and contains an acidic tail.
is predicted to contain alternating sets of alpha helicies and beta strands. No helix-turn-helix
(HTH) regions were predicted.
. No paralogs were found for the cow, mouse, or rat orthologs of WDR75.. Conservation among mammalian orthologs to the human gene was strong, with minimum identity amoug orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acid
s from positions 340-390, 430- 450, and 515-530 all correlate to predicted alpha helicies.
Eukaryote
A eukaryote is an organism whose cells contain complex structures enclosed within membranes. Eukaryotes may more formally be referred to as the taxon Eukarya or Eukaryota. The defining membrane-bound structure that sets eukaryotic cells apart from prokaryotic cells is the nucleus, or nuclear...
types and is known to be involved in cellular regulator functions such as pre-mRNA
Precursor mRNA
Precursor mRNA is an immature single strand of messenger ribonucleic acid . pre-mRNA is synthesized from a DNA template in the cell nucleus by transcription. Pre-mRNA comprises the bulk of heterogeneous nuclear RNA...
processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the scientific community
Scientific community
The scientific community consists of the total body of scientists, its relationships and interactions. It is normally divided into "sub-communities" each working on a particular field within science. Objectivity is expected to be achieved by the scientific method...
.
| Accession Numbers | Location | Identifiers | M.W. | pI |
|---|---|---|---|---|
| NM_032186, NP_115544.1 | 2q32.2 | FLJ12519, DKFZp781N2144 | 94.5 kDa | 5.56 |
Protein Seuqence
The amino acid sequencePeptide sequence
Peptide sequence or amino acid sequence is the order in which amino acid residues, connected by peptide bonds, lie in the chain in peptides and proteins. The sequence is generally reported from the N-terminal end containing free amino group to the C-terminal end containing free carboxyl group...
is 830 residues long and contains an acidic tail.
1 MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV
61 TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC KLHALFTLAQ AEDSVFVIVN
121 KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV LDYINQSPKC IAFGNEGVYV AAVREFYLSV
181 YFFKKKTTSR FTLSSSRNKK HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT
241 YTCLHWHHDM VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
301 AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV LNGKPGHLQF
361 YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN WLATVEQRQE KETELELQMK
421 LWMYNKKTQG FILNTKINMP HEDCITALCF CNAEKSEQPT LVTASKDGYF KVWILTDDSD
481 IYKKAVGWTC DFVGSYHKYQ ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG
541 KIRHLCFGRL TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
601 SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW LNRSQFYFLT
661 KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG KHRQQQDEKL NETLENELVQ
721 LPLTENIPAI SELLHTPAHV LPSAAFLCSM FVNSLLLSKE TKSAKEIPED VDMEEEKESE
781 DSDEENDFTE KVQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
Secondary Structure
The secondary structureSecondary structure
In biochemistry and structural biology, secondary structure is the general three-dimensional form of local segments of biopolymers such as proteins and nucleic acids...
is predicted to contain alternating sets of alpha helicies and beta strands. No helix-turn-helix
Helix-turn-helix
In proteins, the helix-turn-helix is a major structural motif capable of binding DNA. It is composed of two α helices joined by a short strand of amino acids and is found in many proteins that regulate gene expression...
(HTH) regions were predicted.
Homology
No known paralogs exist for the Human geneGene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. No paralogs were found for the cow, mouse, or rat orthologs of WDR75.. Conservation among mammalian orthologs to the human gene was strong, with minimum identity amoug orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acid
Amino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
s from positions 340-390, 430- 450, and 515-530 all correlate to predicted alpha helicies.
| Organism | Accession Number | % Identity to Human Gene |
|---|---|---|
| Bos Taurus | NP_001095532.1 | 91.7 |
| Mus musculus | NP_082875.1 | 84.9 |
| Pan troglodytes | XP_001164827.1 | 99.5 |
| Rattus norvegicus | NP_001041354.1 | 84.3 |
| Canis familiaris | XP_545565 | 90.7 |
| Xenopus Laevis | NP_001086564.1 | 61.0 |
| Gallus gallus | XP_001233408.1 | 60.8 |
| Schizosaccharomyces pombe | NP_594798 | 19.9 |
| Anopheles gambiae | XP_317524 | 22.7 |