WDR5
Encyclopedia
WD repeat-containing protein 5 is a protein
that in humans is encoded by the WDR5 gene
.
with Host cell factor C1
and MLL
. It also interacts with the long non-coding RNA HOTTIP
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the WDR5 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
WDR5 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Host cell factor C1
Host cell factor C1
Host cell factor is a protein that in humans is encoded by the HCFC1 gene.-Interactions:Host cell factor C1 has been shown to interact with HDAC1, Histone deacetylase 2, OGT, SIN3A, SUDS3, ZBTB17, Sp1 transcription factor, MLL, PPP1CA, POU2F1, PDCD2, WDR5, CREB3 and GABPA.-Further reading:...
and MLL
MLL (gene)
Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL gene.MLL is a histone methyltransferase deemed a positive global regulator of gene transcription...
. It also interacts with the long non-coding RNA HOTTIP
HOTTIP
In molecular biology, HOTTIP is a long non-coding RNA. The gene encoding HOTTIP is located at the 5' tip of the HOXA locus, and coordinates the activation of several of the 5' HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping...
.