WAY-213,613
Encyclopedia
WAY-213,613 is a drug which acts as a reuptake inhibitor
for the glutamate transporter
subtype EAAT2
, selective over other glutamate transporter subtypes and highly selective over metabotropic
and ionotropic
glutamate receptor
s. It is used in scientific research into the function of the glutamate transporters.
Reuptake inhibitor
A reuptake inhibitor , also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an...
for the glutamate transporter
Glutamate transporter
Excitatory amino-acid transporters , formerly known as Glutamate transporters, belong to the family of neurotransmitter transporters. They serve to terminate the excitatory neurotransmitter signal by removal of glutamate from the neuronal synapse into Glia cells.In details, the EAATs are...
subtype EAAT2
SLC1A2
Excitatory amino-acid transporter 2 also known as solute carrier family 1 member 2 is a protein that in humans is encoded by the SLC1A2 gene...
, selective over other glutamate transporter subtypes and highly selective over metabotropic
Metabotropic glutamate receptor
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs...
and ionotropic
Ligand-gated ion channel
Ligand-gated ion channels are one type of ionotropic receptor or channel-linked receptor. They are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger , such as a neurotransmitter.The binding site of endogenous ligands on LGICs...
glutamate receptor
Glutamate receptor
Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Glutamate is one of the 20 amino acids used to assemble proteins and as a result is abundant in many areas of the body, but it also functions as a neurotransmitter and is particularly abundant in the...
s. It is used in scientific research into the function of the glutamate transporters.