Vitamin K reactions occur after injection with vitamin K

Vitamin K

Vitamin K is a group of structurally similar, fat soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone derivatives...

, and there are two patterns of presentation, (1) a reaction may occur several days to 2 weeks after inection with skin lesions that are pruritic, red patches and plaques that can deep-seated, involving the dermis

Dermis

The dermis is a layer of skin between the epidermis and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis...

 and subcutaneous tissue

Subcutaneous tissue

The hypodermis, also called the hypoderm, subcutaneous tissue, or superficial fascia is the lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages...

, or (2) with subcutaneous sclerosis with or without fasciitis

Fasciitis

In medicine, fasciitis refers to an inflammation of the fascia. In particular, it often refers to one of the following diseases:* Necrotizing fasciitis* Plantar fasciitis* Eosinophilic fasciitis* Paraneoplastic fasciitis...

, that appears at the site of injection many months after treatment. The latter pseudosclerodermatous reaction has been termed Texier's disease

Texier's disease

Texier's disease is a pseudosclerodermatous reaction that occurs after injection with vitamin K, a subcutaneous sclerosis with or without fasciitis that lasts several years.- References :...

and lasts several years.