Vitamin D-dependent calcium-binding protein
Encyclopedia
Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine
, and later in mammalian intestine and kidney, by workers including Robert Wasserman of Cornell University
.
They bound calcium
in the micromolar range and were greatly reduced in vitamin D
-deficient animals. Expression could be induced by treating these animals with vitamin D
metabolites such as calcitriol
.
They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa. They were renamed calbindin
; calbindin-D9k (S100G
) is found in mammalian intestine and calbindin-D28k in avian intestine and in kidney.
Intestine
In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine...
, and later in mammalian intestine and kidney, by workers including Robert Wasserman of Cornell University
Cornell University
Cornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...
.
They bound calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust...
in the micromolar range and were greatly reduced in vitamin D
Vitamin D
Vitamin D is a group of fat-soluble secosteroids. In humans, vitamin D is unique both because it functions as a prohormone and because the body can synthesize it when sun exposure is adequate ....
-deficient animals. Expression could be induced by treating these animals with vitamin D
Vitamin D
Vitamin D is a group of fat-soluble secosteroids. In humans, vitamin D is unique both because it functions as a prohormone and because the body can synthesize it when sun exposure is adequate ....
metabolites such as calcitriol
Calcitriol
Calcitriol , also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active form of vitamin D with three hydroxyl groups...
.
They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa. They were renamed calbindin
Calbindin
Calbindin refers to several calcium-binding proteins. They were originally described as vitamin D-dependent calcium-binding proteins in the intestine and kidney in the chick and mammals...
; calbindin-D9k (S100G
S100G
Protein S100-G is a protein that in humans is encoded by the S100G gene.-Further reading:...
) is found in mammalian intestine and calbindin-D28k in avian intestine and in kidney.