Velaglucerase alfa
Encyclopedia
Velaglucerase alfa manufactured by Shire plc is a hydrolytic lysosomal glucocerebroside
-specific enzyme, which is a recombinant form of glucocerebrosidase
indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1. It has an identical amino acid sequence to the naturally occurring enzyme. It was approved for use by the U.S. Food and Drug Administration (FDA) on February 26, 2010.
is Genzyme
's version of recombinant glucocerebrosidase. It is marketed globally under the trade name of Cerezyme.
In addition, Protalix and Pfizer
are working to bring taliglucerase alpha
to market in the U.S. The FDA is due to rule on its approvability in February 2011. The companies are expected also to file for marketing authorization in Europe and around the world.
Glucocerebroside
Glucocerebroside is any of the cerebrosides in which the monosaccharide head group is glucose.-Clinical significance:...
-specific enzyme, which is a recombinant form of glucocerebrosidase
Glucocerebrosidase
β-Glucocerebrosidase is an enzyme with glucosylceramidase activity that is needed to cleave, by hydrolysis, the beta-glucosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism...
indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1. It has an identical amino acid sequence to the naturally occurring enzyme. It was approved for use by the U.S. Food and Drug Administration (FDA) on February 26, 2010.
Competitive products
ImigluceraseImiglucerase
Imiglucerase is a medication used in the treatment of Gaucher's disease.It is a recombinant DNA-produced analogue of human β-glucocerebrosidase....
is Genzyme
Genzyme
Genzyme Corporation is a fully owned subsidiary of Sanofi-Aventis. Before its acquisition, Genzyme was an American biotechnology company based in Cambridge, Massachusetts. In 2010, Genzyme was the world’s third-largest biotechnology company, employing more than 11,000 people around the world...
's version of recombinant glucocerebrosidase. It is marketed globally under the trade name of Cerezyme.
In addition, Protalix and Pfizer
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
are working to bring taliglucerase alpha
Taliglucerase alpha
Taliglucerase alfa is a plant-derived enzyme that is currently in phase III clinical trials by Protalix and Pfizer. The enzyme is a recombinant glucocerebrosidase used to treat Gaucher’s Disease. If it is approved by the U.S. Food and Drug Administration it will be first plant-made pharmaceutical...
to market in the U.S. The FDA is due to rule on its approvability in February 2011. The companies are expected also to file for marketing authorization in Europe and around the world.