VMAT1
Encyclopedia
VMAT1 is a protein that transports the monoamines into intracellular vesicle
s.
In chromaffin cell
s, it is responsible for transporting newly synthesized epinephrine
from the cytosol
back into chromaffin granules in preparation for release.
For norepinephrine
to be acted upon by PNMT in the cytosol
, it must first be shipped out of granules of the chromaffin
cells. This may occur via the catecholamine-H+ exchanger VMAT1.
Vesicle (biology)
A vesicle is a bubble of liquid within another liquid, a supramolecular assembly made up of many different molecules. More technically, a vesicle is a small membrane-enclosed sack that can store or transport substances. Vesicles can form naturally because of the properties of lipid membranes , or...
s.
In chromaffin cell
Chromaffin cell
Chromaffin cells are neuroendocrine cells found in the medulla of the adrenal gland and in other ganglia of the sympathetic nervous system. They are modified post-synaptic sympathetic neurons that receive sympathetic input...
s, it is responsible for transporting newly synthesized epinephrine
Epinephrine
Epinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...
from the cytosol
Cytosol
The cytosol or intracellular fluid is the liquid found inside cells, that is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into compartments....
back into chromaffin granules in preparation for release.
For norepinephrine
Norepinephrine
Norepinephrine is the US name for noradrenaline , a catecholamine with multiple roles including as a hormone and a neurotransmitter...
to be acted upon by PNMT in the cytosol
Cytosol
The cytosol or intracellular fluid is the liquid found inside cells, that is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into compartments....
, it must first be shipped out of granules of the chromaffin
Chromaffin
Taking up and staining strongly with Chromium salts.Chromaffin may refer to:*Chromaffin cells, neuroendocrine cells in the adrenal medulla.*Chromophil cells, hormone producing cells showing chromaffin granules that readily absorb chromium stains....
cells. This may occur via the catecholamine-H+ exchanger VMAT1.