Uroporphyrinogen III
Encyclopedia
Uroporphyrinogen III is an metabolic intermediate
Metabolic intermediate
Metabolic intermediates refers to molecules which are the precursors or metabolites of biologically significant molecules.Although these intermediates are of relatively minor direct importance to cellular function, they can play important roles in the allosteric regulation of enzymes.-Clinical...

 in the biosynthesis
Biosynthesis
Biosynthesis is an enzyme-catalyzed process in cells of living organisms by which substrates are converted to more complex products. The biosynthesis process often consists of several enzymatic steps in which the product of one step is used as substrate in the following step...

 of protoporphyrin. It is created by the enzyme uroporphyrinogen III synthase
Uroporphyrinogen III synthase
Uroporphyrinogen III synthase is an enzyme involved in the metabolism of the cyclic tetrapyrrole compound porphyrin. It is involved in the conversion of hydroxymethyl bilane into uroporphyrinogen III...

, and is converted into coproporphyrinogen III
Coproporphyrinogen III
In the metabolism of porphyrin, the enzyme uroporphyrinogen III decarboxylase generates coproporphyrinogen III from uroporphyrinogen III, and coproporphyrinogen III oxidase converts it into protoporphyrinogen IX....

 by the enzyme uroporphyrinogen III decarboxylase
Uroporphyrinogen III decarboxylase
Uroporphyrinogen decarboxylase, also known as UROD, is an enzyme that in humans is encoded by the UROD gene.- Function :This gene encodes the fifth enzyme of the heme biosynthetic pathway...

.

See also

  • Uroporphyrinogen

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