USS Preble may refer to:
was a sloop-of-war that fought at the Battle of Lake Champlain in the War of 1812, was a sloop that fought in the Mexican-American War and the Civil War, and visited Japan. She was accidentally destroyed by fire in 1863, launched in 1901, was a Bainbridge-class destroyer that served in World War I, launched in 1920, was a Clemson-class destroyer that served in the Pacific campaign of World War II, launched in 1959; decommissioned 1991, was a Farragut-class guided missile destroyer which saw action in the Vietnam War., launched in 2001, is an Arleigh Burke-class destroyer currently in commission