USS Potomac or USNS Potomac may refer to one of these United States Navy ships:
, a frigate in commission from 1831 to 1877, a whaler purchased in 1861 and sunk as part of the "Stone Fleet" in 1862, a tug in commission from 1898 to 1922, a presidential yacht in service from 1936 to 1945, an oiler in service from 1957 until destroyed in a fire in 1961, an oiler in service from 1976 to 1983