USS Despatch may refer to:
, a schooner in commission from 1814 to 1820, a sloop-of-war in commission from 1856 to 1859, which was recommissioned as USS Pocahontas

USS Pocahontas (1852)

The first USS Pocahontas, a screw steamer built at Medford, Massachusetts in 1852 as City of Boston, and purchased by the Navy at Boston, Massachusetts on 20 March 1855, was the first United States Navy ship to be named for Pocahontas, the Algonquian wife of Virginia colonist John Rolfe. She was...

 in 1860, served in the American Civil War, and was decommissioned a final time in 1865, a screw steamer in commission from 1873 to 1891, which served as the first Presidential yacht from 1880 until 1891, a ferry launch in commission as USS Steam Cutter No. 423 1902-1908, as USS Despatch 1908-1918, and as USS Hustle 1918-1921, being designated YFB-6 in 1921

• USS Despatch (SP-68)
  USS Despatch (SP-68)
  The fifth USS Despatch , later PY-8, originally USS Vixen , was a yacht that served in the United States Navy as a tender from 1917 to 1919 and from 1920 to 1921.-Construction and acquisition:...
  
  , redesignated PY-8 in 1920, a tender with the Atlantic Fleet in commission as USS Vixen (SP-68) briefly in 1917, then as USS Despatch (SP-68) from 1917 to 1919 and again in 1920, and as USS Despatch (PY-8) from 1920 to 1921, a receiving ship in service under the name from 1940 to 1946, which previously had been the protected cruiser Boston and which was renamed Despatch in 1940 to free the name Boston for the new heavy cruiser USS Boston (CA-69).