UBE1C
Encyclopedia
This enzyme contains an E2 binding domain
, which resembles ubiquitin
, and recruits the catalytic core of the E2 enzyme UBE2M
(Ubc12) in a similar manner to that in which ubiquitin interact
s with ubiquitin binding domains
.
with NEDD8
, APPBP1
and UBE2M
.
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
, which resembles ubiquitin
Ubiquitin
Ubiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms. Among other functions, it directs protein recycling.Ubiquitin can be attached to proteins and label them for destruction...
, and recruits the catalytic core of the E2 enzyme UBE2M
UBE2M
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.-Interactions:UBE2M has been shown to interact with NEDD8, PRKAR1A and UBA3.-Further reading:...
(Ubc12) in a similar manner to that in which ubiquitin interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
s with ubiquitin binding domains
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
.
Interactions
UBE1C has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NEDD8
NEDD8
NEDD8 is a protein that in humans is encoded by the NEDD8 gene. This ubiquitin-like protein , which becomes covalently conjugated to a limited number of cellular proteins in a manner analogous to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin...
, APPBP1
APPBP1
NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.-Interactions:APPBP1 has been shown to interact with UBE1C, TRIP12 and Amyloid precursor protein.-Further reading:...
and UBE2M
UBE2M
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.-Interactions:UBE2M has been shown to interact with NEDD8, PRKAR1A and UBA3.-Further reading:...
.