Tryptophol
Encyclopedia
Tryptophol is a chemical compound that induces sleep in humans. It is formed in the liver after disulfiram
treatment. It is also produced by the trypanosomal parasite in sleeping sickness.
It is also found in wine as a secondary product of alcoholic fermentation. It has been first described by Felix Ehrlich
in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dioxide and re-placing the amino group with hydroxyl. By this reaction, the tryptophan
gives rise to tryptophol.
It is used in the synthesis of the drug indoramin
.
Disulfiram
Disulfiram is a drug discovered in the 1920s and used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals...
treatment. It is also produced by the trypanosomal parasite in sleeping sickness.
It is also found in wine as a secondary product of alcoholic fermentation. It has been first described by Felix Ehrlich
Felix Ehrlich
Felix Ehrlich was a German chemist and biochemist.- Life and work :...
in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dioxide and re-placing the amino group with hydroxyl. By this reaction, the tryptophan
Tryptophan
Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG...
gives rise to tryptophol.
It is used in the synthesis of the drug indoramin
Indoramin
Indoramin is a piperidine antiadrenergic agent.It is an alpha-1 selective adrenoceptor antagonist. with direct myocardial depression action,therefore,it results in no reflex tachycardiaIt is commonly synthesized from tryptophol...
.