The TrkB internal ribosome entry site (IRES) is an RNA element

Cis-regulatory element

A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...

 which is present in the 5' UTR sequence of the mRNA. TrkB

TrkB

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.-Function:...

 is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site

Internal ribosome entry site

An internal ribosome entry site, abbreviated IRES, is a nucleotide sequence that allows for translation initiation in the middle of a messenger RNA sequence as part of the greater process of protein synthesis...

 IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.

See also

• Mnt IRES
  Mnt IRES
  The Mnt internal ribosome entry site is an RNA element. Mnt is a transcriptional repressor related to the Myc/Mad family of transcription factors. It is thought that this IRES allows efficient Mnt synthesis when cap-dependent translation initiation is reduced.-See also:*N-myc IRES*Tobamovirus...
  
  
• N-myc IRES
  N-myc internal ribosome entry site (IRES)
  The N-myc internal ribosome entry site is an RNA element found in the n-myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis...
  
  
• Tobamovirus IRES
  Tobamovirus internal ribosome entry site (IRES)
  The Tobamovirus internal ribosome entry site is an element that allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and...