Triclabendazole
Encyclopedia
Triclabendazole is a member of the benzimidazole
family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate
group.
Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver fluke
s.
Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.
Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health
in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health
. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat Fasciola hepatica
(both immature and adult liver fluke
s), roundworms and ectoparasites, as well.
Benzimidazole
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. The most prominent benzimidazole compound in nature is N-ribosyl-dimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. Benzimidazole, in...
family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate
Carbamate
Carbamates are organic compounds derived from carbamic acid . A carbamate group, carbamate ester, and carbamic acids are functional groups that are inter-related structurally and often are interconverted chemically. Carbamate esters are also called urethanes.-Synthesis:Carbamic acids are derived...
group.
Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver fluke
Liver fluke
Liver flukes are a polyphyletic group of trematodes .Adults of liver flukes are localized in the liver of various mammals, including humans. These flatworms can occur in bile ducts, gallbladder, and liver parenchyma. They feed on blood...
s.
Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.
Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health
Agrovet Market Animal Health
Agrovet Market Animal Health is an international pharmaceutical company with corporate headquarters, in Lima, Peru.Founded in Lima in 1994, Agrovet Market Animal Health is a company involved in the animal healthcare business...
in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health
Agrovet Market Animal Health
Agrovet Market Animal Health is an international pharmaceutical company with corporate headquarters, in Lima, Peru.Founded in Lima in 1994, Agrovet Market Animal Health is a company involved in the animal healthcare business...
. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat Fasciola hepatica
Fasciola hepatica
Fasciola hepatica, also known as the common liver fluke or sheep liver fluke, is a parasitic flatworm of the class Trematoda, phylum Platyhelminthes that infects the livers of various mammals, including humans. The disease caused by the fluke is called fascioliasis . F...
(both immature and adult liver fluke
Liver fluke
Liver flukes are a polyphyletic group of trematodes .Adults of liver flukes are localized in the liver of various mammals, including humans. These flatworms can occur in bile ducts, gallbladder, and liver parenchyma. They feed on blood...
s), roundworms and ectoparasites, as well.