TiLo is a limited company established in 2004 as a joint venture between the Italian State Railways (Trenitalia with the subsidiary) and the Swiss Federal Railways (SBB CFF FFS), both companies participate in the equity of TILO SA with participation of 50%.

The company's goal is to develop the regional cross-border traffic between the Canton Ticino

Ticino

Canton Ticino or Ticino is the southernmost canton of Switzerland. Named after the Ticino river, it is the only canton in which Italian is the sole official language...

 and Lombardy

Lombardy

Lombardy is one of the 20 regions of Italy. The capital is Milan. One-sixth of Italy's population lives in Lombardy and about one fifth of Italy's GDP is produced in this region, making it the most populous and richest region in the country and one of the richest in the whole of Europe...

.

In 2009 the company carried 6,000,000 passengers. Most of the commuters were along the route Como ↔ Chiasso ↔ Mendrisio ↔ Lugano ↔ Bellinzona ↔ Biasca (S10) and Bellinzona ↔ Locarno (S20), served by trains every 30 minutes (every 15 minutes on average on peaks). Line S30 Bellinzona ↔ Luino is served every 2 hours, with a single daily train continuing to Busto Arsizio.

The staff that runs the trains in Italy is supplied by Trenitalia, while and Swiss Federal Railways runs the trains in Switzerland.

The fleet consists of:

• 19 RABe 524.0/ETR 150 FLIRT 4-car EMUs (3 of them temporary in service on Genève-La Plaine line)
• 11 RABe 524.1/ETR 524 FLIRT 6-car EMUs
• some NPZ RBDe 560 EMUs with NPZ driving trailers and EW 1 or EW 2 intermediate coaches (exact number is unknown but variable)

Stadler Flirt trains can run also in Italy, while the older NPZ trains are used only on peak hours trains in Switzerland.

The trains are always accompanied by a driver only, except for the S10 only in the Italian section Chiasso - Albate, where there is also a staff member accompanying the train (conductor).

Routes currently operated

Line	Path	Nation
	(Airolo Airolo Airolo is a municipality in the district of Leventina in the canton of Ticino in Switzerland.-History:In the settlement of Madrano, Roman tombs from the 2nd and 3rd Centuries AD were found. They belonged to a Vicus, whose inhabitants probably collected crystal, which was processed in Locarno into...  -) Biasca Biasca Biasca is a town of the district of Riviera in the canton of Ticino in Switzerland.-History:Biasca is first mentioned in 830 as Aviasca in the Liber viventium of Pfäfers Abbey. In 1119 it was mentioned as Abiasca.-Early history:...  ↔ Bellinzona Bellinzona Bellinzona is the administrative capital of the canton Ticino in Switzerland. The city is famous for its three castles that have been UNESCO World Heritage Sites since 2000....  ↔ Lugano Lugano Lugano is a city of inhabitants in the city proper and a total of over 145,000 people in the agglomeration/city region, in the south of Switzerland, in the Italian-speaking canton of Ticino, which borders Italy...  ↔ Chiasso Chiasso Chiasso is a municipality in the district of Mendrisio in the canton of Ticino in Switzerland.As the southernmost of Switzerland's municipalities, Chiasso is located at the border with Italy, in front of Ponte Chiasso...  ↔ Albate	/
	Bellinzona Bellinzona Bellinzona is the administrative capital of the canton Ticino in Switzerland. The city is famous for its three castles that have been UNESCO World Heritage Sites since 2000....  ↔ Locarno Locarno Locarno is the capital of the Locarno district, located on the northern tip of Lake Maggiore in the Swiss canton of Ticino, close to Ascona at the foot of the Alps. It has a population of about 15,000...
	Bellinzona Bellinzona Bellinzona is the administrative capital of the canton Ticino in Switzerland. The city is famous for its three castles that have been UNESCO World Heritage Sites since 2000....  ↔ Luino Luino Luino is a small town and comune near the border with Switzerland on the eastern shore of Lake Maggiore, in the Province of Varese ....  (- Busto Arsizio Busto Arsizio Busto Arsizio is a city and comune in the region of Lombardy, in northern Italy, 25 km north of Milan in the province of Varese.The economy of Busto Arsizio is mainly based on industry and commerce.-History:... )	/