Transient neonatal diabetes mellitus
Encyclopedia
Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus
presenting at birth that is not permanent.
Types include:
It is to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).
The form on chromosome 6 can involve imprinting.
Diabetes mellitus
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
presenting at birth that is not permanent.
Types include:
| Type | OMIM | Gene | Locus | Description |
|---|---|---|---|---|
| TNDM1 | ZFP57 ZFP57 Zinc finger protein 57 homolog , also known as zinc finger protein 698 , is a protein that in humans is encoded by the ZFP57 gene.- Function :The protein encoded by this gene is a zinc finger protein containing a KRAB domain... |
6p22.1 | ||
| TNDM2 | ABCC8 ABCC8 ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. ABCC8 orthologs have been identified in all mammals for which complete genome data are available.-External links:* *... |
11p15.1 | Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 ABCC8 ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. ABCC8 orthologs have been identified in all mammals for which complete genome data are available.-External links:* *... gene. |
|
| TNDM3 | KCNJ11 | 11p15.1 |
It is to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).
The form on chromosome 6 can involve imprinting.
External links
See also
- Permanent neonatal diabetes mellitusPermanent neonatal diabetes mellitusA newly identified and potentially treatable form of monogenic diabetes is the neonatal diabetes caused by activating mutations of the KCNJ11 gene, which codes for the Kir6.2 subunit of the beta cell KATP channel....