Tom Misteli
Encyclopedia
Tom Misteli, Ph.D. is a Swiss-born cell biologist and pioneer in the field of genome cell biology. He is a Senior Investigator at the National Cancer Institute
, NIH, Bethesda, MD, United States. He is the Editor-in-Chief of The Journal of Cell Biology and Current Opinion in Cell Biology.
Tom Misteli is best known for his work on elucidation of how genomes function in living cells. While a post-doc at the Cold Spring Harbor Laboratory
, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease Hutchinson-Gilford Progeria Syndrome have revealed novel mechanisms of human aging.
National Cancer Institute
The National Cancer Institute is part of the National Institutes of Health , which is one of 11 agencies that are part of the U.S. Department of Health and Human Services. The NCI coordinates the U.S...
, NIH, Bethesda, MD, United States. He is the Editor-in-Chief of The Journal of Cell Biology and Current Opinion in Cell Biology.
Tom Misteli is best known for his work on elucidation of how genomes function in living cells. While a post-doc at the Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory
The Cold Spring Harbor Laboratory is a private, non-profit institution with research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics. The Laboratory has a broad educational mission, including the recently established Watson School of Biological Sciences. It...
, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease Hutchinson-Gilford Progeria Syndrome have revealed novel mechanisms of human aging.