Thrombopoiesis
Encyclopedia
Thrombopoiesis refers to the process of thrombocyte generation.
Thromobocytes are ligations of the cytoplasm
from megakaryocytes. A single megakaryocyte can give rise to thousands of thrombocytes.
The term "thrombocytopoiesis" is sometimes used to emphasize the cellular nature.
Thrombopoietin
stimulates megakaryopoiesis, process of megakaryocyte maturation and differentiation. Thrombopoietin
, upon release, binds to its receptor, c-mpl, found on megakaryocyte
progenitor cells. Following binding, intracellular signalling leads to megakaryocyte
growth
, maturation
, membrane
stability, platelet granule formation and the demarcation of the cytoplasm
into regions destined to fragment into mature platelets. These "proplatelet processes" further fragment into platelet
s. This last step of proplatelet process and platelet
formation, in vitro, has been shown to be independent of thrombopoietin
.
Thromobocytes are ligations of the cytoplasm
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
from megakaryocytes. A single megakaryocyte can give rise to thousands of thrombocytes.
The term "thrombocytopoiesis" is sometimes used to emphasize the cellular nature.
Thrombopoietin
Thrombopoietin
Thrombopoietin also known as megakaryocyte growth and development factor is a protein that in humans is encoded by the THPO gene....
stimulates megakaryopoiesis, process of megakaryocyte maturation and differentiation. Thrombopoietin
Thrombopoietin
Thrombopoietin also known as megakaryocyte growth and development factor is a protein that in humans is encoded by the THPO gene....
, upon release, binds to its receptor, c-mpl, found on megakaryocyte
Megakaryocyte
The megakaryocyte is a bone marrow cell responsible for the production of blood thrombocytes , which are necessary for normal blood clotting...
progenitor cells. Following binding, intracellular signalling leads to megakaryocyte
Megakaryocyte
The megakaryocyte is a bone marrow cell responsible for the production of blood thrombocytes , which are necessary for normal blood clotting...
growth
Growth
Growth refers to an increase in some quantity over time.The quantity can be:*Physical *Abstract ....
, maturation
Maturation
Maturation could refer to any of the following:* Fetal development* Developmental biology* Emotional development* Or physical maturation of any biological life form - see individual articles for maturation of different life forms....
, membrane
Membrane
-In biology:* Biological membrane* Cell membrane, a biological type of Membrane ** Inner membrane** Outer membrane * The two fetal membranes** amnion** chorion* Basement membrane* Mucous membrane* Serous membrane...
stability, platelet granule formation and the demarcation of the cytoplasm
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
into regions destined to fragment into mature platelets. These "proplatelet processes" further fragment into platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
s. This last step of proplatelet process and platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
formation, in vitro, has been shown to be independent of thrombopoietin
Thrombopoietin
Thrombopoietin also known as megakaryocyte growth and development factor is a protein that in humans is encoded by the THPO gene....
.