Thiouracil
Encyclopedia
Thiouracil refers both to a specific molecule consisting of a sulfated uracil
, and a family of molecules based upon that structure. The substance is a historically relevant antithyroid preparation; Astwood E.B. used it in 1943 as therapy of the Graves' disease
for the first time.
Uracil
Uracil is one of the four nucleobases in the nucleic acid of RNA that are represented by the letters A, G, C and U. The others are adenine, cytosine, and guanine. In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine.Uracil is a common and...
, and a family of molecules based upon that structure. The substance is a historically relevant antithyroid preparation; Astwood E.B. used it in 1943 as therapy of the Graves' disease
Graves' disease
Graves' disease is an autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones...
for the first time.